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A novel retinoblastoma therapy from genomic and epigenetic analyses

A novel retinoblastoma therapy from genomic and epigenetic analyses

Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours progress very quickly following RB1 inactivation but the underlying mechanism is not known. Here we show that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated. To identify the mutations [...] [mehr...]

Retinoblastom (Bornfeld et al. 2006)

A multidisciplinary approach to understanding and treating retinoblastoma by ophthalmologists, radiation oncologists, pediatric oncologists and geneticists. [mehr...]

Diagnosis and Current Management of Retinoblastoma (Balmer et al 2006)

This gives you a link to a very interesting retinoblastoma review article (overview). [mehr...]

Retinoblastoma (Abramson et al. 2004)

Educational Article about retinoblastoma for doctors and scientists. [mehr...]